AL-LAD
AL-LAD is a semi-synthetic psychedelic of the lysergamide class and a close structural analog of LSD. First described in scientific literature during the 1970s,citation needed it was further investigated by Andrew J. Hoffman and David Nichols in 1984 and subsequently documented by Alexander Shulgin in TiHKAL.1 It entered the research chemical market around 2013 as a grey-market alternative to LSD.citation needed Users often report enhanced visual activity with comparatively reduced cognitive intensity relative to LSD.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
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Effects vary widely by individual, dose, and context.
Physical
Cognitive
In comparison to other psychedelics such as Psilocin, LSA and Ayahuasca, AL-LAD is significantly more stimulating and fast paced in terms of the specific style of thought stream which it produces and contains a large number of potential effects.
Visual
Geometry
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 2C-B or 2C-I than Psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, organic in feel, multicoloured in scheme, flat in shading, soft in its edges, large in size, slow in speed, smooth in motion, round in its corners, unimmersive in depth and consistent in intensity. At higher dosages, it consistently results in states of Level 8A visual geometry over Level 8B.
Distortions
Hallucinatory States
AL-LAD is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics.
Auditory
The auditory effects of AL-LAD are common in their occurrence and exhibit a full range of effects.
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
AL-LAD acts as an agonist at the serotonin 5-HT2A receptor, which is considered the primary mechanism underlying its psychedelic effects.citation needed It displays high binding affinity for this receptor23, though sources disagree on whether it functions as a full agonist or a partial agonist. AL-LAD also interacts with other serotonin receptors in the 5-HT1 family2 and shows affinity for dopamine D1 and D2 receptors.3
Pharmacokinetics
An in vitro study using pooled human liver S9 fractions identified eleven tentative AL-LAD metabolites formed through N-dealkylation, hydroxylation, combinations of those reactions, and glucuronidation. Recombinant-enzyme experiments implicated CYP3A4 in N6-deallylation, N-deethylation, and hydroxylation, and CYP1A2 in hydroxylation.4 These experiments were qualitative and were designed to identify metabolic products and enzymes; they did not measure human absorption, bioavailability, clearance, or elimination half-life. The shorter reported duration of AL-LAD therefore should not be presented as evidence that it is metabolized faster than LSD.citation needed
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Serotonergic psychedelics (LSD, psilocybin, mescaline, DMT), Other 5-HT2A agonists
Harm Potential
Addiction & Dependence
Psychological
Extremely LowAL-LAD is non-habit forming and the desire to use it can actually decrease with use.citation needed It is considered self-regulating in the same manner as LSD and other classic psychedelics.
Physical
Extremely LowNo physical dependence or withdrawal symptoms have been documented. As with LSD, AL-LAD does not appear to produce physical dependencecitation needed, though formal studies have not been conducted.
Psychosis Risk
AL-LAD may act as a potential trigger for psychotic episodes in those with underlying psychiatric conditions. Those with a personal or family history of mental illness are advised not to use this substance.citation needed Delusions and adverse psychological reactions become more likely at higher doses, though overt psychosis appears uncommon in otherwise healthy individuals using the substance alone.
Seizure Risk
Seizures are rare but have been reported, primarily in those who are genetically predisposed to them,citation needed particularly when accompanied by physically taxing conditions such as dehydration, fatigue, or undernourishment. Those with preexisting seizure disorders should avoid AL-LAD.
History & Culture
AL-LAD was first synthesized and described in the scientific literature in 1976.citation needed The compound received further attention in 1984 when researchers Andrew J. Hoffman and David Nichols investigated it as part of a broader series of LSD analogues, which also included ETH-LAD and…
Legality
International
1961 Single Convention: AL-LAD is not individually scheduled.
1971 Convention on Psychotropic Substances: AL-LAD is not individually scheduled.
1988 Convention: AL-LAD is not listed in precursor Tables I or II.
By Country
References
Source Pages
Citations
Article Status
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