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Phenethylamine is pharmacologically inactive when taken alone due to rapid metabolism by monoamine oxidase. Misuse in combination with MAO inhibitors has been reported, though abuse potential is not well characterized.
Phenethylamine is rapidly metabolized by monoamine oxidase, which significantly affects its toxicity profile in vivo. LDLo (lowest lethal dose) values include 800 mg/kg orally in rats and 300 mg/kg in mice via unspecified route.
| Species | Route | Value |
|---|---|---|
| mouse | intraperitoneal | 175 mg/kg |
| mouse | subcutaneous | 320 mg/kg |
| mouse | intravenous | 100 mg/kg |
| mouse | parenteral | 100 mg/kg |
| mouse | intracervical | 39 mg/kg |
| guinea pig | intraperitoneal | 200 mg/kg |
Acts as a potent antimicrobial against certain pathogenic strains of Escherichia coli, including the O157:H7 strain, at sufficient concentrations.
Phenethylamine has long held a special place in psychopharmacological research due to its status as the simplest member of the phenethylamine chemical class. Its clean molecular structure, natural presence in human tissues and bodily fluids, and close chemical relationship to both amphetamine and…
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