Methallylescaline
Methallylescaline (MAL) is a synthetic1 psychedelic1 of the substituted phenethylamine class and a structural analog of mescaline.2 Its effects were first described by Alexander Shulgin in PiHKAL, with anecdotal reports suggesting it most closely resembles mescaline among the various mescaline analogs, producing both hallucinogenic and stimulantcitation needed properties. Very little data exists regarding its pharmacology, metabolism, or toxicity,3 and it has minimal history of human use.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Methallylescaline has a steep dose-response relationship, meaning relatively small increases in the amount taken may result in disproportionately stronger effects. Careful attention to precise dosing is advisable.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Hallucinatory States
Auditory
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
Methallylescaline acts as an agonist at serotonin 5-HT2 receptors,citation needed with primary activity at the 5-HT2A receptor. It has been described both as a potent 5-HT2A agonist4 and as a likely 5-HT2A partial agonist. It also interacts with the 5-HT2C receptor.4
Pharmacokinetics
The metabolism of Methallylescaline has been studied. Methallylescaline is proposed to undergo hydroxylation, O-dealkylation, carboxylation, deamination and dihydroxylation of the allyl group.citation needed
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowMethallylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Psychosis Risk
Delusion is listed among possible cognitive effects. Some reports mention experiences described as 'shades of what might become amnesia' and 'losing immediate contact,' though formal psychosis risk has not been evaluated due to the substance's limited research history.citation needed
History & Culture
Methallylescaline was first synthesized and explored by American chemist Alexander Shulgin, who initially experimented with the compound in 1981. The following year, in 1982, Shulgin discovered its hallucinogenic properties. He subsequently documented his findings in his 1991 book PiHKAL: A…
Legality
By Country
GermanyIllegal
United KingdomIllegal
United StatesRestricted
SwitzerlandRestricted
CanadaNot scheduledReferences
Citations
Article Status
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