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These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
High abuse potential similar to other potent benzodiazepines. Compulsive redosing is commonly reported, and rebound anxiety following use can contribute to cycles of dependence and addiction.
Extremely physically addictive with potentially life-threatening withdrawal. Abrupt discontinuation after regular use can result in hypertension, seizures, or death. Gradual tapering over weeks is essential; abrupt cessation is dangerous.
Low toxicity relative to dose when used alone. However, overdose becomes potentially fatal when combined with other depressants such as alcohol, opioids, or barbiturates, which can cause severe respiratory depression, coma, permanent brain injury, or death.
Unusually for a benzodiazepine, high to very high doses have reportedly caused seizures without additional triggers such as withdrawal. This proconvulsant effect at high doses is atypical for the drug class. Seizures are also a significant risk during withdrawal from chronic use.
Flunitrazolam is a novel designer benzodiazepine with no documented history prior to its emergence on the online research chemical market. Unlike many benzodiazepines which were first developed by pharmaceutical companies and later diverted to recreational use, flunitrazolam appears to have been…
Legal as of September 2021. Not a scheduled or controlled substance under Swiss narcotics law.
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