Allylescaline
Allylescaline is a psychedelic substance in the phenethylamine and scaline classes, and is structurally related to mescaline and escaline. Otakar Leminger reported the compound in 1972,1 and Alexander Shulgin later discussed it in his 1991 book PiHKAL.citation needed It appeared as a novel designer drug in 2013. Allylescaline remains relatively uncommon, with little documented history of human use.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
In a 2025 in-vitro receptor screen, Allylescaline (allylmescaline) showed measurable binding at 5-HT1E, 5-HT2A, 5-HT2B and 5-HT2C. Binding was strongest at 5-HT2B among these measured targets. These affinity measurements do not by themselves establish partial- or full-agonist efficacy, human receptor occupancy, clinical potency or safety. [S1][S2]
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of allylescaline and the metabolism of allylescaline is unknown.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowAllylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Physical
Extremely LowNo evidence of physical dependence. The substance is described as not habit-forming.
History & Culture
Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972.citation needed The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings in the 1991 book…
Legality
By Country
References
Source Pages
Citations
Further Reading
Article Status
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