Skip to main content
dose.wiki is still in beta. Entries may contain inaccuracies and/or lack citations. See our docs for more info.

4-AcO-MiPT

4-AcO-MiPT molecule structure4-AcO-MiPT molecule structure
4-Acetoxy-N-methyl-N-isopropyltryptamine
Mipracetin, O-Acetylmiprocin
Psychoactive Class
Chemical Class
Tryptamine

4-AcO-MiPT is a synthetic psychedelic of the tryptamine class.1 It is the acetylated form of 4-HO-MiPT and a higher homolog of 4-AcO-DMT, commonly hypothesized to act primarily as a prodrug for its hydroxylated counterpart, though whether it possesses innate activity of its own remains debated. Very little is known about its human pharmacology or toxicity. It remains relatively uncommon, with minimal history of human use, and is primarily acquired through online research chemical vendors.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~5 mg
Light10-15 mg
Moderate15-20 mg
Strong20-35 mg
Heavy35+ mg

Duration

Onset15-45 minutes
Come Up60-120 minutes
Peak1.5-3 hours
Offset1-2 hours
After Effects2-4 hours
Total4-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Runny noseWatery eyes

Cognitive

The cognitive effects of 4-AcO-MiPT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating.

Visual

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, unimmersive in depth and consistent in intensity. The visuals have a very 'natural' feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory States

4-AcO-MiPT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.

Transformations

Auditory

The auditory effects of 4-AcO-MiPT are common in their occurrence and exhibit a full range of effects.

Adapted from the 4-HO-MiPT subjective effects documentation. 4-AcO-MiPT is the acetylated prodrug of 4-HO-MiPT and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation byJosie Kins July 2014.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → orange2 → yellow3
Ehrlich(EH)
white → purple2 → purple3 → black3
Hofmann(HM)
white → yellow1
Morr(MO)
pink2 → green1
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

4-AcO-MiPT has demonstrated direct activity at human 5-HT2 receptors in vitro. In calcium-mobilization assays it acted as a high-efficacy 5-HT2A agonist (EC50 43.9 nM; Emax 93.2%), a partial 5-HT2B agonist (EC50 44.7 nM; Emax 49.1%), and a lower-potency partial 5-HT2C agonist (EC50 542 nM; Emax 33.7%). These are functional potency and efficacy values, not binding affinities.2

In mice, 4-AcO-MiPT induced the 5-HT2A-associated head-twitch response with an ED50 of 1.11 mg/kg (2.84 µmol/kg). Its similar molar head-twitch potency to 4-HO-MiPT, despite being less potent in vitro at 5-HT2A, was interpreted by the study authors as consistent with in-vivo deacetylation; the study did not directly measure conversion of 4-AcO-MiPT to 4-HO-MiPT.2

Pharmacokinetics

The available compound-specific study supports a prodrug hypothesis indirectly: acetylation reduced in-vitro 5-HT2A potency, whereas 4-AcO-MiPT and 4-HO-MiPT had similar molar potency in the mouse head-twitch assay. Direct formation of 4-HO-MiPT was not measured, and human bioavailability, metabolic enzymes, plasma kinetics, and elimination half-life remain uncharacterized by this study.2

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

Powered by TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Develops almost immediately after ingestion.
Baseline Reset
7 days
Half Tolerance
Approximately 3 days
Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Not considered habit-forming; the desire to use typically decreases rather than increases with repeated consumption. Like most classical psychedelics, it demonstrates self-regulating properties.citation needed

History & Culture

4-AcO-MiPT is a synthetic psychedelic tryptaminecitation needed that remains relatively obscure within the broader landscape of psychoactive substances. Unlike many classical psychedelics with decades of documented use, this compound has accumulated very little history of human consumption and

Legality

International

4-AcO-MiPT is not listed in the inspected current schedules of the 1971 Convention on Psychotropic Substances; its status under the 1961 and 1988 conventions remains a research gap.

By Country

Illegal5
Germany flagGermanyIllegal (analog/blanket ban)
Japan flagJapanIllegal
Norway flagNorwayIllegal
Sweden flagSwedenIllegal
United Kingdom flagUnited KingdomIllegal
Controlled / restricted2
Finland flagFinlandRestricted
Switzerland flagSwitzerlandRestricted
Not scheduled1
United States flagUnited StatesNot scheduled

References

Source Pages

  1. Erowid
  2. Isomer Design (TiHKAL/PiHKAL)
  3. Isomer Design: 4-AcO-MIPT
  4. PsychonautWiki
  5. The Big & Dandy 4-AcO-MiPT Thread (Bluelight)
  6. TripSit Factsheets
  7. Wikipedia

Citations

  1. Gatch MB, Hoch A, & Carbonaro TM. (2020-12-29). Discriminative Stimulus Effects of Substituted Tryptamines in Rats. ACS Pharmacology & Translational Science, 4(2), 467–471. https://doi.org/10.1021/acsptsci.0c001731
  2. Klein AK, Chatha M, Laskowski LJ, Anderson EI, Brandt SD, Chapman SJ, McCorvy JD, & Halberstadt AL. (2020-12-14). Investigation of the Structure–Activity Relationships of Psilocybin Analogues. ACS Pharmacology & Translational Science, 4(2), 533–542. https://doi.org/10.1021/acsptsci.0c001761234
  3. 指定薬物を指定する省令が公布されました (MHLW announcement of the ordinance promulgated 25 March 2015). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20150325.html1
  4. (別紙)新たに指定された指定薬物の名称 [Attachment to the 25 March 2015 announcement: names of the newly designated substances]. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/dl/20150325.pdf1
  5. 指定薬物一覧 [List of designated substances]. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf1
  6. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律第二条第十五項に規定する指定薬物及び同法第七十六条の四に規定する医療等の用途を定める省令(平成十九年厚生労働省令第十四号), e-Gov consolidated text. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/lawdata/419M600001000141
  7. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律(昭和三十五年法律第百四十五号)第二条第十五項, e-Gov. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/articles;lawId=335AC0000000145;article=%E7%AC%AC%E4%BA%8C%E6%9D%A1;paragraph=151
  8. 同法第七十六条の四(製造等の禁止), e-Gov. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/articles;lawId=335AC0000000145;article=%E7%AC%AC%E4%B8%83%E5%8D%81%E5%85%AD%E6%9D%A1%E3%81%AE%E5%9B%9B1
  9. 同法第八十四条(罰則), e-Gov. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/articles;lawId=335AC0000000145;article=%E7%AC%AC%E5%85%AB%E5%8D%81%E5%9B%9B%E6%9D%A11
  10. 同法第八十三条の九(罰則), e-Gov. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/articles;lawId=335AC0000000145;article=%E7%AC%AC%E5%85%AB%E5%8D%81%E4%B8%89%E6%9D%A1%E3%81%AE%E4%B9%9D1

Further Reading

  1. Takahashi et al. - Psychoactive Designer Drugs Data Library

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • L
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the 4-AcO-MiPT article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.